Kelch domain-containing protein 8A (KLHDC8A)
Homo sapiens — UniProt Q8IYD2
Data last refreshed: (UniProt release unknown)
Key facts
Kelch domain-containing protein 8A (KLHDC8A) is a protein from Homo sapiens identified by UniProt accession Q8IYD2, 350 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q8IYD2; gene symbol KLHDC8A.
- Organism: Homo sapiens.
- Length: 350 amino acids.
- Top disease associations (Open Targets): Abnormality of refraction, glioblastoma and papillary thyroid carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch domain-containing protein 8A |
|---|---|
| UniProt accession | Q8IYD2 |
| Gene | KLHDC8A |
| Organism | Homo sapiens |
| Length | 350 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- Abnormality of refraction · score 0.28
- glioblastoma · score 0.06
- papillary thyroid carcinoma · score 0.05
- esophageal squamous cell carcinoma · score 0.03
- sex hormone-binding globulin measurement · score 0.03
- sleep measurement · score 0.03
- mean platelet volume · score 0.03
- Leishmaniasis · score 0.02
- neoplasm · score 0.02
- platelet-to-lymphocyte ratio · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYD2-F1 | alphafold | PREDICTED | 95.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYD2.
Amino-acid sequence (350 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHDC8A?
The strongest Open Targets associations for KLHDC8A are Abnormality of refraction, glioblastoma, papillary thyroid carcinoma, esophageal squamous cell carcinoma and sex hormone-binding globulin measurement.
How long is the KLHDC8A protein?
The Homo sapiens KLHDC8A protein (UniProt Q8IYD2) is 350 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYD2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYD2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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