Lung adenoma susceptibility protein 2 (LAS2)
Homo sapiens — UniProt Q8IYD9
Data last refreshed: (UniProt release unknown)
Key facts
Lung adenoma susceptibility protein 2 (LAS2) is a protein from Homo sapiens identified by UniProt accession Q8IYD9, 372 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q8IYD9; gene symbol LAS2.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): wellbeing measurement, testosterone measurement and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lung adenoma susceptibility protein 2 |
|---|---|
| UniProt accession | Q8IYD9 |
| Gene | LAS2 |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- wellbeing measurement · score 0.37
- testosterone measurement · score 0.29
- leukocyte count · score 0.29
- neuroticism measurement · score 0.27
- depressive symptom measurement · score 0.27
- cortical thickness · score 0.25
- systolic blood pressure · score 0.16
- diastolic blood pressure · score 0.12
- asthma · score 0.08
- Eczematoid dermatitis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYD9-F1 | alphafold | PREDICTED | 59.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYD9.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LAS2?
The strongest Open Targets associations for LAS2 are wellbeing measurement, testosterone measurement, leukocyte count, neuroticism measurement and depressive symptom measurement.
How long is the LAS2 protein?
The Homo sapiens LAS2 protein (UniProt Q8IYD9) is 372 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYD9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYD9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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