Coiled-coil domain-containing protein 146 (CCDC146)
Homo sapiens — UniProt Q8IYE0
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 146 (CCDC146) is a protein from Homo sapiens identified by UniProt accession Q8IYE0, 955 residues long. MolForge cross-references it against 0 known binders and 202 disease associations.
- UniProt accession: Q8IYE0; gene symbol CCDC146.
- Organism: Homo sapiens.
- Length: 955 amino acids.
- Top disease associations (Open Targets): Male infertility with spermatogenesis disorder due to single gene mutation, Male infertility due to sperm motility disorder and diabetic eye disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 146 |
|---|---|
| UniProt accession | Q8IYE0 |
| Gene | CCDC146 |
| Organism | Homo sapiens |
| Length | 955 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (202)
Diseases linked to this target (Open Targets).
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.43
- Male infertility due to sperm motility disorder · score 0.42
- diabetic eye disease · score 0.29
- macrovascular complications of diabetes · score 0.29
- appendicular lean mass · score 0.25
- waist-hip ratio · score 0.25
- blood protein measurement · score 0.23
- amyloid-beta measurement · score 0.21
- body mass index · score 0.18
- drug use measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYE0-F1 | alphafold | PREDICTED | 78.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYE0.
Amino-acid sequence (955 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC146?
The strongest Open Targets associations for CCDC146 are Male infertility with spermatogenesis disorder due to single gene mutation, Male infertility due to sperm motility disorder, diabetic eye disease, macrovascular complications of diabetes and appendicular lean mass.
How long is the CCDC146 protein?
The Homo sapiens CCDC146 protein (UniProt Q8IYE0) is 955 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYE0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYE0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.