Shieldin complex subunit 1 (SHLD1)
Homo sapiens — UniProt Q8IYI0
Data last refreshed: (UniProt release unknown)
Key facts
Shieldin complex subunit 1 (SHLD1) is a protein from Homo sapiens identified by UniProt accession Q8IYI0, 205 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q8IYI0; gene symbol SHLD1.
- Organism: Homo sapiens.
- Length: 205 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, heel bone mineral density and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Shieldin complex subunit 1 |
|---|---|
| UniProt accession | Q8IYI0 |
| Gene | SHLD1 |
| Organism | Homo sapiens |
| Length | 205 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.38
- heel bone mineral density · score 0.33
- BMI-adjusted hip circumference · score 0.33
- waist-hip ratio · score 0.33
- BMI-adjusted waist circumference · score 0.30
- Blackfan-Diamond anemia · score 0.07
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
- hemoglobin D disease · score 0.05
- IRIDA syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYI0-F1 | alphafold | PREDICTED | 66.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYI0.
Amino-acid sequence (205 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHLD1?
The strongest Open Targets associations for SHLD1 are BMI-adjusted waist-hip ratio, heel bone mineral density, BMI-adjusted hip circumference, waist-hip ratio and BMI-adjusted waist circumference.
How long is the SHLD1 protein?
The Homo sapiens SHLD1 protein (UniProt Q8IYI0) is 205 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYI0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYI0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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