Exocyst complex component 8 (EXOC8)
Homo sapiens — UniProt Q8IYI6
Data last refreshed: (UniProt release unknown)
Key facts
Exocyst complex component 8 (EXOC8) is a protein from Homo sapiens identified by UniProt accession Q8IYI6, 725 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q8IYI6; gene symbol EXOC8.
- Organism: Homo sapiens.
- Length: 725 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neurodevelopmental disorder with microcephaly, seizures, and brain atrophy and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exocyst complex component 8 |
|---|---|
| UniProt accession | Q8IYI6 |
| Gene | EXOC8 |
| Organism | Homo sapiens |
| Length | 725 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- neurodevelopmental disorder with microcephaly, seizures, and brain atrophy · score 0.46
- hemoglobin measurement · score 0.29
- high altitude adaptation · score 0.16
- hematocrit · score 0.15
- whole body water mass · score 0.13
- squamous cell lung carcinoma · score 0.12
- Joubert syndrome · score 0.11
- head and neck squamous cell carcinoma · score 0.09
- lymphocyte percentage of leukocytes · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYI6-F1 | alphafold | PREDICTED | 73.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYI6.
Amino-acid sequence (725 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXOC8?
The strongest Open Targets associations for EXOC8 are neurodegenerative disease, neurodevelopmental disorder with microcephaly, seizures, and brain atrophy, hemoglobin measurement, high altitude adaptation and hematocrit.
How long is the EXOC8 protein?
The Homo sapiens EXOC8 protein (UniProt Q8IYI6) is 725 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYI6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYI6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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