Zinc finger protein 440 (ZNF440)
Homo sapiens — UniProt Q8IYI8
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 440 (ZNF440) is a protein from Homo sapiens identified by UniProt accession Q8IYI8, 595 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q8IYI8; gene symbol ZNF440.
- Organism: Homo sapiens.
- Length: 595 amino acids.
- Top disease associations (Open Targets): vitamin D measurement, leukocyte count and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 440 |
|---|---|
| UniProt accession | Q8IYI8 |
| Gene | ZNF440 |
| Organism | Homo sapiens |
| Length | 595 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.39
- leukocyte count · score 0.32
- neutrophil count · score 0.31
- blood phosphate measurement · score 0.27
- IGF-1 measurement · score 0.26
- myeloid white cell count · score 0.17
- Down syndrome · score 0.04
- eosinophil count · score 0.03
- microphthalmia with limb anomalies · score 0.01
- rosacea · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYI8-F1 | alphafold | PREDICTED | 61.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYI8.
Amino-acid sequence (595 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF440?
The strongest Open Targets associations for ZNF440 are vitamin D measurement, leukocyte count, neutrophil count, blood phosphate measurement and IGF-1 measurement.
How long is the ZNF440 protein?
The Homo sapiens ZNF440 protein (UniProt Q8IYI8) is 595 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYI8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYI8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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