Synaptotagmin-like protein 1 (SYTL1)
Homo sapiens — UniProt Q8IYJ3
Data last refreshed: (UniProt release unknown)
Key facts
Synaptotagmin-like protein 1 (SYTL1) is a protein from Homo sapiens identified by UniProt accession Q8IYJ3, 562 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q8IYJ3; gene symbol SYTL1.
- Organism: Homo sapiens.
- Length: 562 amino acids.
- Top disease associations (Open Targets): blood protein measurement, blood pressure and common variable immunodeficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptotagmin-like protein 1 |
|---|---|
| UniProt accession | Q8IYJ3 |
| Gene | SYTL1 |
| Organism | Homo sapiens |
| Length | 562 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.11
- blood pressure · score 0.06
- common variable immunodeficiency · score 0.05
- isolated agammaglobulinemia · score 0.05
- annular pancreas · score 0.05
- immunodeficiency 72 with autoinflammation · score 0.05
- immunodeficiency 18 · score 0.04
- gamma chain deficiency · score 0.04
- T-B+ severe combined immunodeficiency due to JAK3 deficiency · score 0.04
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYJ3-F1 | alphafold | PREDICTED | 72.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYJ3.
Amino-acid sequence (562 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SYTL1?
The strongest Open Targets associations for SYTL1 are blood protein measurement, blood pressure, common variable immunodeficiency, isolated agammaglobulinemia and annular pancreas.
How long is the SYTL1 protein?
The Homo sapiens SYTL1 protein (UniProt Q8IYJ3) is 562 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYJ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYJ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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