UPF0688 protein C1orf174 (C1orf174)
Homo sapiens — UniProt Q8IYL3
Data last refreshed: (UniProt release unknown)
Key facts
UPF0688 protein C1orf174 (C1orf174) is a protein from Homo sapiens identified by UniProt accession Q8IYL3, 243 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8IYL3; gene symbol C1orf174.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cutaneous melanoma and neuroblastoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | UPF0688 protein C1orf174 |
|---|---|
| UniProt accession | Q8IYL3 |
| Gene | C1orf174 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- cutaneous melanoma · score 0.17
- neuroblastoma · score 0.17
- smoking status measurement · score 0.17
- PHF-tau measurement · score 0.16
- migraine disorder · score 0.13
- asthma · score 0.13
- response to diisocyanate · score 0.13
- gut microbiome measurement · score 0.12
- hip bone size · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYL3-F1 | alphafold | PREDICTED | 60.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYL3.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with C1orf174?
The strongest Open Targets associations for C1orf174 are neurodegenerative disease, cutaneous melanoma, neuroblastoma, smoking status measurement and PHF-tau measurement.
How long is the C1orf174 protein?
The Homo sapiens C1orf174 protein (UniProt Q8IYL3) is 243 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYL3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYL3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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