G-protein coupled receptor 65 (GPR65)
Homo sapiens — UniProt Q8IYL9
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor 65 (GPR65) is a protein from Homo sapiens identified by UniProt accession Q8IYL9, 337 residues long. MolForge cross-references it against 0 known binders and 162 disease associations.
- UniProt accession: Q8IYL9; gene symbol GPR65.
- Organism: Homo sapiens.
- Length: 337 amino acids.
- Top disease associations (Open Targets): inflammatory bowel disease, Crohn's disease and basophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor 65 |
|---|---|
| UniProt accession | Q8IYL9 |
| Gene | GPR65 |
| Organism | Homo sapiens |
| Length | 337 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (162)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.46
- Crohn's disease · score 0.45
- basophil count · score 0.44
- ankylosing spondylitis · score 0.43
- eosinophil count · score 0.42
- multiple sclerosis · score 0.41
- ulcerative colitis · score 0.41
- Parkinson disease · score 0.40
- eosinophil percentage of leukocytes · score 0.32
- psoriasis · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYL9-F1 | alphafold | PREDICTED | 82.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYL9.
Amino-acid sequence (337 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR65?
The strongest Open Targets associations for GPR65 are inflammatory bowel disease, Crohn's disease, basophil count, ankylosing spondylitis and eosinophil count.
How long is the GPR65 protein?
The Homo sapiens GPR65 protein (UniProt Q8IYL9) is 337 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYL9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYL9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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