Protein FAM186B (FAM186B)
Homo sapiens — UniProt Q8IYM0
Data last refreshed: (UniProt release unknown)
Key facts
Protein FAM186B (FAM186B) is a protein from Homo sapiens identified by UniProt accession Q8IYM0, 893 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q8IYM0; gene symbol FAM186B.
- Organism: Homo sapiens.
- Length: 893 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, systolic blood pressure and nephronophthisis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein FAM186B |
|---|---|
| UniProt accession | Q8IYM0 |
| Gene | FAM186B |
| Organism | Homo sapiens |
| Length | 893 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.29
- systolic blood pressure · score 0.28
- nephronophthisis · score 0.26
- smoking status measurement · score 0.15
- vital capacity · score 0.11
- attention deficit hyperactivity disorder · score 0.11
- substance abuse · score 0.10
- antisocial behaviour measurement · score 0.10
- hypertension · score 0.09
- forced expiratory volume · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYM0-F1 | alphafold | PREDICTED | 62.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYM0.
Amino-acid sequence (893 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM186B?
The strongest Open Targets associations for FAM186B are pulse pressure measurement, systolic blood pressure, nephronophthisis, smoking status measurement and vital capacity.
How long is the FAM186B protein?
The Homo sapiens FAM186B protein (UniProt Q8IYM0) is 893 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYM0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYM0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.