Septin-12 (SEPTIN12)
Homo sapiens — UniProt Q8IYM1
Data last refreshed: (UniProt release unknown)
Key facts
Septin-12 (SEPTIN12) is a protein from Homo sapiens identified by UniProt accession Q8IYM1, 358 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: Q8IYM1; gene symbol SEPTIN12.
- Organism: Homo sapiens.
- Length: 358 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 10, non-syndromic male infertility due to sperm motility disorder and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Septin-12 |
|---|---|
| UniProt accession | Q8IYM1 |
| Gene | SEPTIN12 |
| Organism | Homo sapiens |
| Length | 358 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- spermatogenic failure 10 · score 0.58
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- spermatogenic failure 65 · score 0.10
- spermatogenic failure 56 · score 0.10
- spermatogenic failure 72 · score 0.09
- spermatogenic failure, X-linked, 3 · score 0.09
- spermatogenic failure 39 · score 0.09
- spermatogenic failure 46 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYM1-F1 | alphafold | PREDICTED | 81.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYM1.
Amino-acid sequence (358 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEPTIN12?
The strongest Open Targets associations for SEPTIN12 are spermatogenic failure 10, non-syndromic male infertility due to sperm motility disorder, azoospermia, male infertility with teratozoospermia due to single gene mutation and spermatogenic failure 65.
How long is the SEPTIN12 protein?
The Homo sapiens SEPTIN12 protein (UniProt Q8IYM1) is 358 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYM1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYM1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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