E3 ubiquitin-protein ligase TRIM22 (TRIM22)
Homo sapiens — UniProt Q8IYM9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRIM22 (TRIM22) is a protein from Homo sapiens identified by UniProt accession Q8IYM9, 498 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q8IYM9; gene symbol TRIM22.
- Organism: Homo sapiens.
- Length: 498 amino acids.
- Top disease associations (Open Targets): Crohn's disease, inflammatory bowel disease and visual perception measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM22 |
|---|---|
| UniProt accession | Q8IYM9 |
| Gene | TRIM22 |
| Organism | Homo sapiens |
| Length | 498 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- Crohn's disease · score 0.47
- inflammatory bowel disease · score 0.40
- visual perception measurement · score 0.26
- lymphocyte count · score 0.23
- platelet count · score 0.12
- glioblastoma multiforme · score 0.10
- alkaline phosphatase measurement · score 0.10
- hepatocellular carcinoma · score 0.10
- mean platelet volume · score 0.09
- sex hormone-binding globulin measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYM9-F1 | alphafold | PREDICTED | 85.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYM9.
Amino-acid sequence (498 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM22?
The strongest Open Targets associations for TRIM22 are Crohn's disease, inflammatory bowel disease, visual perception measurement, lymphocyte count and platelet count.
How long is the TRIM22 protein?
The Homo sapiens TRIM22 protein (UniProt Q8IYM9) is 498 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYM9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYM9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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