Xaa-Arg dipeptidase (PM20D2)
Homo sapiens — UniProt Q8IYS1
Data last refreshed: (UniProt release unknown)
Key facts
Xaa-Arg dipeptidase (PM20D2) is a protein from Homo sapiens identified by UniProt accession Q8IYS1, 436 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q8IYS1; gene symbol PM20D2.
- Organism: Homo sapiens.
- Length: 436 amino acids.
- Top disease associations (Open Targets): blood metabolite measurement, serum metabolite measurement and sleep duration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Xaa-Arg dipeptidase |
|---|---|
| UniProt accession | Q8IYS1 |
| Gene | PM20D2 |
| Organism | Homo sapiens |
| Length | 436 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- blood metabolite measurement · score 0.28
- serum metabolite measurement · score 0.21
- sleep duration · score 0.11
- body height · score 0.10
- neutrophil percentage of leukocytes · score 0.07
- monocyte count · score 0.05
- mental or behavioural disorder · score 0.04
- monocyte percentage of leukocytes · score 0.03
- breast carcinoma · score 0.02
- acute quadriplegic myopathy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYS1-F1 | alphafold | PREDICTED | 93.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYS1.
Amino-acid sequence (436 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PM20D2?
The strongest Open Targets associations for PM20D2 are blood metabolite measurement, serum metabolite measurement, sleep duration, body height and neutrophil percentage of leukocytes.
How long is the PM20D2 protein?
The Homo sapiens PM20D2 protein (UniProt Q8IYS1) is 436 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYS1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYS1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.