Dynein axonemal assembly factor 8 (DNAAF8)

About Dynein axonemal assembly factor 8

Dynein axonemal assembly factor 8 (DNAAF8) is a protein from Homo sapiens identified by UniProt accession Q8IYS4, 520 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Dynein axonemal assembly factor 8
UniProt accession	Q8IYS4
Gene	DNAAF8
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

protein measurement · score 0.32
ferritin measurement · score 0.21
pulse pressure measurement · score 0.03
alkaline phosphatase measurement · score 0.03
vital capacity · score 0.02
body height · score 0.02
hepatocellular carcinoma · score 0.00
infection · score 0.00
infect · score 0.00
cyst · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IYS4-F1	alphafold	PREDICTED	53.65	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYS4.

Amino-acid sequence (520 residues)

MASNDKGMAP SLGSPWASQM GPWDAILKAV KDQLPSLDSD SPLSDYGEEE LFIFQRNQTS LIPDLSEELA EDPADGDKSR AWVAAAEESL PEPVLVPAEL ATEPGCRQNT RTKDASSQEG RDPGRPFESS GEVSALLGMA EEPPRWLEGD LGSLSFNTKG SQGPPWDPQA EATLSCHEGD PKAEPLSTAS QESVNRRALR QERRKMIETD ILQKVTRDAC GPTSSDKGGV KEAPCHAAES APRSKMPLVE PPEGPPVLSL QQLEAWDLDD ILQSLAGQED NQGNRAPGTV WWAADHRQVQ DRMVPSAHNR LMEQLALLCT TQSKASACAR KVPADTPQDT KEADSGSRCA SRKQGSQAGP GPQLAQGMRL NAESPTIFID LRQMELPDHL SPESSSHSSS DSEEEEEEEM AALGDAEGAS PSSLGLRTCT GKSQLLQQLR AFQKGTAQPE LPASKGPAGG RAQAPEDTAG SRTGRKQHMK LCAKGQSAQA RLPRGRPRAL GDVPEPGAAR EALMPPLEQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards