Osteoclast-associated immunoglobulin-like receptor (OSCAR)
Homo sapiens — UniProt Q8IYS5
Data last refreshed: (UniProt release unknown)
Key facts
Osteoclast-associated immunoglobulin-like receptor (OSCAR) is a protein from Homo sapiens identified by UniProt accession Q8IYS5, 282 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q8IYS5; gene symbol OSCAR.
- Organism: Homo sapiens.
- Length: 282 amino acids.
- Top disease associations (Open Targets): blood protein measurement, microphthalmia with limb anomalies and Rheumatoid arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Osteoclast-associated immunoglobulin-like receptor |
|---|---|
| UniProt accession | Q8IYS5 |
| Gene | OSCAR |
| Organism | Homo sapiens |
| Length | 282 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.28
- microphthalmia with limb anomalies · score 0.08
- Rheumatoid arthritis · score 0.08
- cancer · score 0.08
- neutropenia-monocytopenia-deafness syndrome · score 0.04
- neoplasm · score 0.03
- Crohn's disease · score 0.03
- lung adenocarcinoma · score 0.03
- glioblastoma multiforme · score 0.02
- Sepsis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYS5-F1 | alphafold | PREDICTED | 79.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYS5.
Amino-acid sequence (282 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OSCAR?
The strongest Open Targets associations for OSCAR are blood protein measurement, microphthalmia with limb anomalies, Rheumatoid arthritis, cancer and neutropenia-monocytopenia-deafness syndrome.
How long is the OSCAR protein?
The Homo sapiens OSCAR protein (UniProt Q8IYS5) is 282 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYS5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYS5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.