Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (CMTR2)
Homo sapiens — UniProt Q8IYT2
Data last refreshed: (UniProt release unknown)
Key facts
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (CMTR2) is a protein from Homo sapiens identified by UniProt accession Q8IYT2, 770 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8IYT2; gene symbol CMTR2.
- Organism: Homo sapiens.
- Length: 770 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lung adenocarcinoma and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 |
|---|---|
| UniProt accession | Q8IYT2 |
| Gene | CMTR2 |
| Organism | Homo sapiens |
| Length | 770 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- lung adenocarcinoma · score 0.30
- neuroticism measurement · score 0.28
- non-small cell lung carcinoma · score 0.26
- overall survival · score 0.22
- mood instability measurement · score 0.20
- adolescent idiopathic scoliosis · score 0.20
- feeling tense measurement · score 0.18
- pulse pressure measurement · score 0.07
- haptoglobin measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYT2-F1 | alphafold | PREDICTED | 85.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYT2.
Amino-acid sequence (770 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CMTR2?
The strongest Open Targets associations for CMTR2 are neurodegenerative disease, lung adenocarcinoma, neuroticism measurement, non-small cell lung carcinoma and overall survival.
How long is the CMTR2 protein?
The Homo sapiens CMTR2 protein (UniProt Q8IYT2) is 770 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYT2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYT2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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