Katanin p60 ATPase-containing subunit A-like 2 (KATNAL2)
Homo sapiens — UniProt Q8IYT4
Data last refreshed: (UniProt release unknown)
Key facts
Katanin p60 ATPase-containing subunit A-like 2 (KATNAL2) is a protein from Homo sapiens identified by UniProt accession Q8IYT4, 538 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.
- UniProt accession: Q8IYT4; gene symbol KATNAL2.
- Organism: Homo sapiens.
- Length: 538 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Katanin p60 ATPase-containing subunit A-like 2 |
|---|---|
| UniProt accession | Q8IYT4 |
| Gene | KATNAL2 |
| Organism | Homo sapiens |
| Length | 538 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (144)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- blood protein measurement · score 0.24
- self reported educational attainment · score 0.24
- conscientiousness measurement · score 0.21
- P-selectin glycoprotein ligand 1 measurement · score 0.20
- heel bone mineral density · score 0.18
- intelligence · score 0.18
- schizophrenia · score 0.18
- creatinine measurement · score 0.14
- genetic disorder · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYT4-F1 | alphafold | PREDICTED | 71.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYT4.
Amino-acid sequence (538 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KATNAL2?
The strongest Open Targets associations for KATNAL2 are neurodegenerative disease, blood protein measurement, self reported educational attainment, conscientiousness measurement and P-selectin glycoprotein ligand 1 measurement.
How long is the KATNAL2 protein?
The Homo sapiens KATNAL2 protein (UniProt Q8IYT4) is 538 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYT4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYT4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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