Serine/threonine-protein kinase ULK2 (ULK2)
Homo sapiens — UniProt Q8IYT8
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase ULK2 (ULK2) is a protein from Homo sapiens identified by UniProt accession Q8IYT8, 1036 residues long. MolForge cross-references it against 8 known binders and 79 disease associations.
- UniProt accession: Q8IYT8; gene symbol ULK2.
- Organism: Homo sapiens.
- Length: 1036 amino acids.
- Top disease associations (Open Targets): Abnormal brain morphology, prostate carcinoma and prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase ULK2 |
|---|---|
| UniProt accession | Q8IYT8 |
| Gene | ULK2 |
| Organism | Homo sapiens |
| Length | 1036 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- Abnormal brain morphology · score 0.27
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- schizophrenia · score 0.07
- major depressive disorder · score 0.06
- attention deficit hyperactivity disorder · score 0.06
- obsessive-compulsive disorder · score 0.06
- platelet count · score 0.06
- mean platelet volume · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYT8-F1 | alphafold | PREDICTED | 58.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYT8.
Amino-acid sequence (1036 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ULK2?
The strongest Open Targets associations for ULK2 are Abnormal brain morphology, prostate carcinoma, prostate cancer, Familial prostate cancer and schizophrenia.
How long is the ULK2 protein?
The Homo sapiens ULK2 protein (UniProt Q8IYT8) is 1036 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYT8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYT8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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