E3 ubiquitin-protein ligase HACE1 (HACE1)
Homo sapiens — UniProt Q8IYU2
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase HACE1 (HACE1) is a protein from Homo sapiens identified by UniProt accession Q8IYU2, 909 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q8IYU2; gene symbol HACE1.
- Organism: Homo sapiens.
- Length: 909 amino acids.
- Top disease associations (Open Targets): spastic paraplegia-severe developmental delay-epilepsy syndrome, Seizure and Spastic paraplegia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase HACE1 |
|---|---|
| UniProt accession | Q8IYU2 |
| Gene | HACE1 |
| Organism | Homo sapiens |
| Length | 909 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- spastic paraplegia-severe developmental delay-epilepsy syndrome · score 0.75
- Seizure · score 0.57
- Spastic paraplegia · score 0.48
- age at first sexual intercourse measurement · score 0.35
- Global developmental delay · score 0.33
- Generalized hypotonia · score 0.33
- smoking status measurement · score 0.33
- neuroblastoma · score 0.30
- self reported educational attainment · score 0.28
- body weight · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYU2-F1 | alphafold | PREDICTED | 83.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYU2.
Amino-acid sequence (909 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HACE1?
The strongest Open Targets associations for HACE1 are spastic paraplegia-severe developmental delay-epilepsy syndrome, Seizure, Spastic paraplegia, age at first sexual intercourse measurement and Global developmental delay.
How long is the HACE1 protein?
The Homo sapiens HACE1 protein (UniProt Q8IYU2) is 909 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYU2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYU2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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