Calcium uptake protein 2, mitochondrial (MICU2)
Homo sapiens — UniProt Q8IYU8
Data last refreshed: (UniProt release unknown)
Key facts
Calcium uptake protein 2, mitochondrial (MICU2) is a protein from Homo sapiens identified by UniProt accession Q8IYU8, 434 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.
- UniProt accession: Q8IYU8; gene symbol MICU2.
- Organism: Homo sapiens.
- Length: 434 amino acids.
- Top disease associations (Open Targets): electrocardiography, refractive error measurement and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium uptake protein 2, mitochondrial |
|---|---|
| UniProt accession | Q8IYU8 |
| Gene | MICU2 |
| Organism | Homo sapiens |
| Length | 434 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (96)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.45
- refractive error measurement · score 0.44
- PR interval · score 0.40
- heel bone mineral density · score 0.39
- brain measurement · score 0.32
- PR segment · score 0.28
- open-angle glaucoma · score 0.14
- cortical surface area measurement · score 0.11
- glaucoma · score 0.09
- BMI-adjusted waist-hip ratio · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYU8-F1 | alphafold | PREDICTED | 74.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYU8.
Amino-acid sequence (434 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MICU2?
The strongest Open Targets associations for MICU2 are electrocardiography, refractive error measurement, PR interval, heel bone mineral density and brain measurement.
How long is the MICU2 protein?
The Homo sapiens MICU2 protein (UniProt Q8IYU8) is 434 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYU8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYU8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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