Cilia- and flagella-associated protein 46 (CFAP46)
Homo sapiens — UniProt Q8IYW2
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 46 (CFAP46) is a protein from Homo sapiens identified by UniProt accession Q8IYW2, 2715 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q8IYW2; gene symbol CFAP46.
- Organism: Homo sapiens.
- Length: 2715 amino acids.
- Top disease associations (Open Targets): protein measurement, Heterotaxy and visual perception measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 46 |
|---|---|
| UniProt accession | Q8IYW2 |
| Gene | CFAP46 |
| Organism | Homo sapiens |
| Length | 2715 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.28
- Heterotaxy · score 0.11
- visual perception measurement · score 0.02
- bone density · score 0.02
- urate measurement · score 0.02
- hepatocellular carcinoma · score 0.01
- squamous cell carcinoma · score 0.01
- Colon Sessile Serrated Adenoma/Polyp · score 0.01
- neoplasm · score 0.00
- respiratory tract infectious disorder · score 0.00
3D Structure (8)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYW2-F1 | alphafold | PREDICTED | 83.09 | — |
| AF-Q8IYW2-F2 | alphafold | PREDICTED | 78.39 | — |
| AF-Q8IYW2-F3 | alphafold | PREDICTED | 78.35 | — |
| AF-Q8IYW2-F4 | alphafold | PREDICTED | 75.08 | — |
| AF-Q8IYW2-F5 | alphafold | PREDICTED | 74.01 | — |
| AF-Q8IYW2-F6 | alphafold | PREDICTED | 72.22 | — |
| AF-Q8IYW2-F7 | alphafold | PREDICTED | 68.19 | — |
| AF-Q8IYW2-F8 | alphafold | PREDICTED | 66.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYW2.
Amino-acid sequence (2715 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP46?
The strongest Open Targets associations for CFAP46 are protein measurement, Heterotaxy, visual perception measurement, bone density and urate measurement.
How long is the CFAP46 protein?
The Homo sapiens CFAP46 protein (UniProt Q8IYW2) is 2715 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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