ENTH domain-containing protein 1 (ENTHD1)
Homo sapiens — UniProt Q8IYW4
Data last refreshed: (UniProt release unknown)
Key facts
ENTH domain-containing protein 1 (ENTHD1) is a protein from Homo sapiens identified by UniProt accession Q8IYW4, 607 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q8IYW4; gene symbol ENTHD1.
- Organism: Homo sapiens.
- Length: 607 amino acids.
- Top disease associations (Open Targets): response to statin, Renal insufficiency and Varicose veins.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ENTH domain-containing protein 1 |
|---|---|
| UniProt accession | Q8IYW4 |
| Gene | ENTHD1 |
| Organism | Homo sapiens |
| Length | 607 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- response to statin · score 0.32
- Renal insufficiency · score 0.21
- Varicose veins · score 0.14
- eosinophil count · score 0.11
- mental or behavioural disorder · score 0.09
- multiple sclerosis · score 0.09
- eosinophil percentage of leukocytes · score 0.08
- mean platelet volume · score 0.07
- systemic lupus erythematosus · score 0.05
- blood protein measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYW4-F1 | alphafold | PREDICTED | 56.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYW4.
Amino-acid sequence (607 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENTHD1?
The strongest Open Targets associations for ENTHD1 are response to statin, Renal insufficiency, Varicose veins, eosinophil count and mental or behavioural disorder.
How long is the ENTHD1 protein?
The Homo sapiens ENTHD1 protein (UniProt Q8IYW4) is 607 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYW4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYW4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.