E3 ubiquitin-protein ligase RNF168 (RNF168)
Homo sapiens — UniProt Q8IYW5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF168 (RNF168) is a protein from Homo sapiens identified by UniProt accession Q8IYW5, 571 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: Q8IYW5; gene symbol RNF168.
- Organism: Homo sapiens.
- Length: 571 amino acids.
- Top disease associations (Open Targets): RIDDLE syndrome, neurodegenerative disease and low grade glioma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF168 |
|---|---|
| UniProt accession | Q8IYW5 |
| Gene | RNF168 |
| Organism | Homo sapiens |
| Length | 571 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- RIDDLE syndrome · score 0.74
- neurodegenerative disease · score 0.44
- low grade glioma · score 0.28
- breast adenocarcinoma · score 0.28
- endometrial cancer · score 0.28
- glioblastoma multiforme · score 0.28
- lung adenocarcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.25
- total blood protein measurement · score 0.24
- systolic blood pressure · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYW5-F1 | alphafold | PREDICTED | 61.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYW5.
Amino-acid sequence (571 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF168?
The strongest Open Targets associations for RNF168 are RIDDLE syndrome, neurodegenerative disease, low grade glioma, breast adenocarcinoma and endometrial cancer.
How long is the RNF168 protein?
The Homo sapiens RNF168 protein (UniProt Q8IYW5) is 571 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYW5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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