TBC1 domain family member 21 (TBC1D21)
Homo sapiens — UniProt Q8IYX1
Data last refreshed: (UniProt release unknown)
Key facts
TBC1 domain family member 21 (TBC1D21) is a protein from Homo sapiens identified by UniProt accession Q8IYX1, 336 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.
- UniProt accession: Q8IYX1; gene symbol TBC1D21.
- Organism: Homo sapiens.
- Length: 336 amino acids.
- Top disease associations (Open Targets): exfoliation syndrome, body weight and bipolar I disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC1 domain family member 21 |
|---|---|
| UniProt accession | Q8IYX1 |
| Gene | TBC1D21 |
| Organism | Homo sapiens |
| Length | 336 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (119)
Diseases linked to this target (Open Targets).
- exfoliation syndrome · score 0.30
- body weight · score 0.22
- bipolar I disorder · score 0.21
- age at first birth measurement · score 0.17
- wellbeing measurement · score 0.16
- fat body mass · score 0.16
- appendicular lean mass · score 0.16
- neuroticism measurement · score 0.13
- depressive symptom measurement · score 0.13
- azoospermia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYX1-F1 | alphafold | PREDICTED | 93.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYX1.
Amino-acid sequence (336 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBC1D21?
The strongest Open Targets associations for TBC1D21 are exfoliation syndrome, body weight, bipolar I disorder, age at first birth measurement and wellbeing measurement.
How long is the TBC1D21 protein?
The Homo sapiens TBC1D21 protein (UniProt Q8IYX1) is 336 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.