Coiled-coil domain-containing protein 116 (CCDC116)
Homo sapiens — UniProt Q8IYX3
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 116 (CCDC116) is a protein from Homo sapiens identified by UniProt accession Q8IYX3, 613 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q8IYX3; gene symbol CCDC116.
- Organism: Homo sapiens.
- Length: 613 amino acids.
- Top disease associations (Open Targets): MODY, high density lipoprotein cholesterol measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 116 |
|---|---|
| UniProt accession | Q8IYX3 |
| Gene | CCDC116 |
| Organism | Homo sapiens |
| Length | 613 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- MODY · score 0.11
- high density lipoprotein cholesterol measurement · score 0.09
- type 2 diabetes mellitus · score 0.08
- pulse pressure measurement · score 0.08
- total cholesterol measurement · score 0.08
- lymphocyte count · score 0.07
- rheumatoid arthritis · score 0.07
- type 1 diabetes mellitus · score 0.07
- Red cell distribution width · score 0.07
- diabetes mellitus, transient neonatal, 2 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYX3-F1 | alphafold | PREDICTED | 49.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYX3.
Amino-acid sequence (613 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC116?
The strongest Open Targets associations for CCDC116 are MODY, high density lipoprotein cholesterol measurement, type 2 diabetes mellitus, pulse pressure measurement and total cholesterol measurement.
How long is the CCDC116 protein?
The Homo sapiens CCDC116 protein (UniProt Q8IYX3) is 613 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYX3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYX3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.