Dead end protein homolog 1 (DND1)
Homo sapiens — UniProt Q8IYX4
Data last refreshed: (UniProt release unknown)
Key facts
Dead end protein homolog 1 (DND1) is a protein from Homo sapiens identified by UniProt accession Q8IYX4, 353 residues long. MolForge cross-references it against 0 known binders and 201 disease associations.
- UniProt accession: Q8IYX4; gene symbol DND1.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Top disease associations (Open Targets): Familial prostate cancer, prostate cancer and gonadoblastoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dead end protein homolog 1 |
|---|---|
| UniProt accession | Q8IYX4 |
| Gene | DND1 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (201)
Diseases linked to this target (Open Targets).
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.10
- gonadoblastoma · score 0.09
- Hereditary breast and ovarian cancer syndrome · score 0.09
- ovarian cancer · score 0.08
- cancer · score 0.08
- breast-ovarian cancer, familial, susceptibility to, 1 · score 0.08
- azoospermia · score 0.08
- Testicular Germ Cell Tumor · score 0.08
- melanoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYX4-F1 | alphafold | PREDICTED | 79.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYX4.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DND1?
The strongest Open Targets associations for DND1 are Familial prostate cancer, prostate cancer, gonadoblastoma, Hereditary breast and ovarian cancer syndrome and ovarian cancer.
How long is the DND1 protein?
The Homo sapiens DND1 protein (UniProt Q8IYX4) is 353 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYX4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYX4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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