Centrosomal protein CEP57L1 (CEP57L1)
Homo sapiens — UniProt Q8IYX8
Data last refreshed: (UniProt release unknown)
Key facts
Centrosomal protein CEP57L1 (CEP57L1) is a protein from Homo sapiens identified by UniProt accession Q8IYX8, 460 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q8IYX8; gene symbol CEP57L1.
- Organism: Homo sapiens.
- Length: 460 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, neurofibrillary tangles measurement and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centrosomal protein CEP57L1 |
|---|---|
| UniProt accession | Q8IYX8 |
| Gene | CEP57L1 |
| Organism | Homo sapiens |
| Length | 460 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.29
- neurofibrillary tangles measurement · score 0.29
- mean corpuscular volume · score 0.28
- Red cell distribution width · score 0.26
- mean corpuscular hemoglobin concentration · score 0.26
- prostate carcinoma · score 0.24
- erythrocyte count · score 0.23
- mean corpuscular hemoglobin · score 0.23
- red blood cell density measurement · score 0.22
- hematocrit · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IYX8-F1 | alphafold | PREDICTED | 72.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IYX8.
Amino-acid sequence (460 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEP57L1?
The strongest Open Targets associations for CEP57L1 are high density lipoprotein cholesterol measurement, neurofibrillary tangles measurement, mean corpuscular volume, Red cell distribution width and mean corpuscular hemoglobin concentration.
How long is the CEP57L1 protein?
The Homo sapiens CEP57L1 protein (UniProt Q8IYX8) is 460 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IYX8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IYX8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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