Phosphatase and actin regulator 4 (PHACTR4)
Homo sapiens — UniProt Q8IZ21
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatase and actin regulator 4 (PHACTR4) is a protein from Homo sapiens identified by UniProt accession Q8IZ21, 702 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q8IZ21; gene symbol PHACTR4.
- Organism: Homo sapiens.
- Length: 702 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, systolic blood pressure and diet measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatase and actin regulator 4 |
|---|---|
| UniProt accession | Q8IZ21 |
| Gene | PHACTR4 |
| Organism | Homo sapiens |
| Length | 702 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.27
- systolic blood pressure · score 0.20
- diet measurement · score 0.19
- smoking status measurement · score 0.16
- lymphocyte count · score 0.15
- protein measurement · score 0.13
- self reported educational attainment · score 0.11
- brain measurement · score 0.11
- eosinophil count · score 0.09
- mean reticulocyte volume · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZ21-F1 | alphafold | PREDICTED | 57.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZ21.
Amino-acid sequence (702 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHACTR4?
The strongest Open Targets associations for PHACTR4 are pulse pressure measurement, systolic blood pressure, diet measurement, smoking status measurement and lymphocyte count.
How long is the PHACTR4 protein?
The Homo sapiens PHACTR4 protein (UniProt Q8IZ21) is 702 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZ21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZ21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.