Ras and EF-hand domain-containing protein (RASEF)
Homo sapiens — UniProt Q8IZ41
Data last refreshed: (UniProt release unknown)
Key facts
Ras and EF-hand domain-containing protein (RASEF) is a protein from Homo sapiens identified by UniProt accession Q8IZ41, 740 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q8IZ41; gene symbol RASEF.
- Organism: Homo sapiens.
- Length: 740 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ras and EF-hand domain-containing protein |
|---|---|
| UniProt accession | Q8IZ41 |
| Gene | RASEF |
| Organism | Homo sapiens |
| Length | 740 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- mean corpuscular volume · score 0.19
- type 2 diabetes mellitus · score 0.17
- chronotype measurement · score 0.16
- mean corpuscular hemoglobin concentration · score 0.15
- pulse pressure measurement · score 0.14
- PR interval · score 0.14
- PHF-tau measurement · score 0.12
- neurofibrillary tangles measurement · score 0.11
- chronic obstructive pulmonary disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZ41-F1 | alphafold | PREDICTED | 70.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZ41.
Amino-acid sequence (740 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RASEF?
The strongest Open Targets associations for RASEF are neurodegenerative disease, mean corpuscular volume, type 2 diabetes mellitus, chronotype measurement and mean corpuscular hemoglobin concentration.
How long is the RASEF protein?
The Homo sapiens RASEF protein (UniProt Q8IZ41) is 740 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZ41 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZ41 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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