About Ras and EF-hand domain-containing protein
Ras and EF-hand domain-containing protein (RASEF) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ41, 740 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Ras and EF-hand domain-containing protein |
|---|
| UniProt accession | Q8IZ41 |
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| Gene | RASEF |
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| Organism | Homo sapiens |
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| Length | 740 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- mean corpuscular volume · score 0.19
- type 2 diabetes mellitus · score 0.17
- chronotype measurement · score 0.16
- mean corpuscular hemoglobin concentration · score 0.15
- pulse pressure measurement · score 0.14
- PR interval · score 0.14
- PHF-tau measurement · score 0.12
- neurofibrillary tangles measurement · score 0.11
- chronic obstructive pulmonary disease · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ41-F1 | alphafold | PREDICTED | 70.15 | — |
Amino-acid sequence (740 residues)
MEADGDGEEL ARLRSVFAAC DANRSGRLER EEFRALCTEL RVRPADAEAV FQRLDADRDG AITFQEFARG FLGSLRGGRR RDWGPLDPAP AVSEAGPETH DSEEDEGDED AAAALATSCG PASPGRAWQD FQARLGDEAK FIPREEQVST LYQNINLVEP RLIQPYEHVI KNFIREIRLQ STEMENLAIA VKRAQDKAAM QLSELEEEMD QRIQAAEHKT RKDEKRKAEE ALSDLRRQYE TEVGDLQVTI KKLRKLEEQS KRVSQKEDVA ALKKQIYDLS MENQKVKKDL LEAQTNIAFL QSELDALKSD YADQSLNTER DLEIIRAYTE DRNSLERQIE ILQTANRKLH DSNDGLRSAL ENSYSKFNRS LHINNISPGN TISRSSPKFI GHSPQPLGYD RSSRSSYVDE DCDSLALCDP LQRTNCEVDS LPESCFDSGL STLRDPNEYD SEVEYKHQRG FQRSHGVQES FGGDASDTDV PDIRDEETFG LEDVASVLDW KPQGSVSEGS IVSSSRKPIS ALSPQTDLVD DNAKSFSSQK AYKIVLAGDA AVGKSSFLMR LCKNEFRENI SATLGVDFQM KTLIVDGERT VLQLWDTAGQ ERFRSIAKSY FRKADGVLLL YDVTCEKSFL NIREWVDMIE DAAHETVPIM LVGNKADIRD TAATEGQKCV PGHFGEKLAM TYGALFCETS AKDGSNIVEA VLHLAREVKK RTDKDDSRSI TNLTGTNSKK SPQMKNCCNG
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