Proline-rich protein 22 (PRR22)
Homo sapiens — UniProt Q8IZ63
Data last refreshed: (UniProt release unknown)
Key facts
Proline-rich protein 22 (PRR22) is a protein from Homo sapiens identified by UniProt accession Q8IZ63, 422 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q8IZ63; gene symbol PRR22.
- Organism: Homo sapiens.
- Length: 422 amino acids.
- Top disease associations (Open Targets): red blood cell density measurement, autism spectrum disorder and risk-taking behaviour.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proline-rich protein 22 |
|---|---|
| UniProt accession | Q8IZ63 |
| Gene | PRR22 |
| Organism | Homo sapiens |
| Length | 422 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- red blood cell density measurement · score 0.05
- autism spectrum disorder · score 0.02
- risk-taking behaviour · score 0.02
- chronotype measurement · score 0.02
- nonpapillary renal cell carcinoma · score 0.00
- non-small cell lung carcinoma · score 0.00
- cancer · score 0.00
- lung adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZ63-F1 | alphafold | PREDICTED | 51.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZ63.
Amino-acid sequence (422 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRR22?
The strongest Open Targets associations for PRR22 are red blood cell density measurement, autism spectrum disorder, risk-taking behaviour, chronotype measurement and nonpapillary renal cell carcinoma.
How long is the PRR22 protein?
The Homo sapiens PRR22 protein (UniProt Q8IZ63) is 422 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZ63 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZ63 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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