About Proline-rich protein 22
Proline-rich protein 22 (PRR22) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ63, 422 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Proline-rich protein 22 |
|---|
| UniProt accession | Q8IZ63 |
|---|
| Gene | PRR22 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 422 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (8)
Diseases linked to this target (Open Targets).
- red blood cell density measurement · score 0.05
- autism spectrum disorder · score 0.02
- risk-taking behaviour · score 0.02
- chronotype measurement · score 0.02
- nonpapillary renal cell carcinoma · score 0.00
- non-small cell lung carcinoma · score 0.00
- cancer · score 0.00
- lung adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ63-F1 | alphafold | PREDICTED | 51.82 | — |
Amino-acid sequence (422 residues)
MQHPKPFCAP AAPQEGFSPQ SLEGAEVLGN QPAPTCAEPP PAMGSLNLYH PPDPEKEVFP APPAGFQMAP CGCFFDPRIY RIEWTTPDLG QSALYKLAAS SGGPAGVPSA PGSYLLEPQP YLKAPGLPPY PHYQQAPGGP QFLLPYFPPE GPGPEALGFV GDAGPAAFVE LPLPPLEEGP APLPPPPPKE NKPPPVLITL PAEPTLPPDA YSHLQGHLGH FPGPEPLAFP VKELQGSGAR PGVPLYPPGL SELKVAEVKE GALLGAGKAK APKTARALAL PDKVLLEDAM KLFDCLPGAS EPEGTLCEVP GPALPDSSGG NSADDIRSLC LPEELLSFDY SVPEILDTVS NVDYFFNFKA LDEEQPPHPG PPATNTPAPI LSGKRKASTA KKGKPGRKAR QPAGPASATP PGPREDLGAT PH
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