Dyslexia-associated protein KIAA0319-like protein (KIAA0319L)
Homo sapiens — UniProt Q8IZA0
Data last refreshed: (UniProt release unknown)
Key facts
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) is a protein from Homo sapiens identified by UniProt accession Q8IZA0, 1049 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q8IZA0; gene symbol KIAA0319L.
- Organism: Homo sapiens.
- Length: 1049 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with teratozoospermia due to single gene mutation and systemic scleroderma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dyslexia-associated protein KIAA0319-like protein |
|---|---|
| UniProt accession | Q8IZA0 |
| Gene | KIAA0319L |
| Organism | Homo sapiens |
| Length | 1049 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- systemic scleroderma · score 0.09
- systemic lupus erythematosus · score 0.09
- sex hormone-binding globulin measurement · score 0.08
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 10 · score 0.07
- spermatogenic failure 11 · score 0.07
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 39 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZA0-F1 | alphafold | PREDICTED | 71.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZA0.
Amino-acid sequence (1049 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KIAA0319L?
The strongest Open Targets associations for KIAA0319L are azoospermia, male infertility with teratozoospermia due to single gene mutation, systemic scleroderma, systemic lupus erythematosus and sex hormone-binding globulin measurement.
How long is the KIAA0319L protein?
The Homo sapiens KIAA0319L protein (UniProt Q8IZA0) is 1049 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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