Histone H1.8 (H1-8)
Homo sapiens — UniProt Q8IZA3
Data last refreshed: (UniProt release unknown)
Key facts
Histone H1.8 (H1-8) is a protein from Homo sapiens identified by UniProt accession Q8IZA3, 346 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q8IZA3; gene symbol H1-8.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): intraocular pressure measurement, BMI-adjusted waist-hip ratio and cortical thickness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone H1.8 |
|---|---|
| UniProt accession | Q8IZA3 |
| Gene | H1-8 |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- intraocular pressure measurement · score 0.10
- BMI-adjusted waist-hip ratio · score 0.10
- cortical thickness · score 0.09
- total cholesterol measurement · score 0.08
- body height · score 0.08
- type 2 diabetes mellitus · score 0.08
- MODY · score 0.06
- low density lipoprotein cholesterol measurement · score 0.05
- muscular disease · score 0.05
- isolated asymptomatic elevation of creatine phosphokinase · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZA3-F1 | alphafold | PREDICTED | 59.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZA3.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with H1-8?
The strongest Open Targets associations for H1-8 are intraocular pressure measurement, BMI-adjusted waist-hip ratio, cortical thickness, total cholesterol measurement and body height.
How long is the H1-8 protein?
The Homo sapiens H1-8 protein (UniProt Q8IZA3) is 346 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZA3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZA3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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