Interferon lambda-3 (IFNL3)
Homo sapiens — UniProt Q8IZI9
Data last refreshed: (UniProt release unknown)
Key facts
Interferon lambda-3 (IFNL3) is a protein from Homo sapiens identified by UniProt accession Q8IZI9, 196 residues long. MolForge cross-references it against 0 known binders and 231 disease associations.
- UniProt accession: Q8IZI9; gene symbol IFNL3.
- Organism: Homo sapiens.
- Length: 196 amino acids.
- Top disease associations (Open Targets): chronic hepatitis C virus infection, hepatitis C virus infection and ovarian mucinous adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interferon lambda-3 |
|---|---|
| UniProt accession | Q8IZI9 |
| Gene | IFNL3 |
| Organism | Homo sapiens |
| Length | 196 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (231)
Diseases linked to this target (Open Targets).
- chronic hepatitis C virus infection · score 0.27
- hepatitis C virus infection · score 0.26
- ovarian mucinous adenocarcinoma · score 0.25
- liver neoplasm · score 0.20
- hepatocellular carcinoma · score 0.18
- Ovarian cyst · score 0.16
- low density lipoprotein cholesterol measurement · score 0.16
- viral load · score 0.14
- mathematical ability · score 0.12
- mitochondrial heteroplasmy measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZI9-F1 | alphafold | PREDICTED | 84.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZI9.
Amino-acid sequence (196 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFNL3?
The strongest Open Targets associations for IFNL3 are chronic hepatitis C virus infection, hepatitis C virus infection, ovarian mucinous adenocarcinoma, liver neoplasm and hepatocellular carcinoma.
How long is the IFNL3 protein?
The Homo sapiens IFNL3 protein (UniProt Q8IZI9) is 196 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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