Interferon lambda-2 (IFNL2)
Homo sapiens — UniProt Q8IZJ0
Data last refreshed: (UniProt release unknown)
Key facts
Interferon lambda-2 (IFNL2) is a protein from Homo sapiens identified by UniProt accession Q8IZJ0, 200 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.
- UniProt accession: Q8IZJ0; gene symbol IFNL2.
- Organism: Homo sapiens.
- Length: 200 amino acids.
- Top disease associations (Open Targets): ulcerative colitis, neoplasm and allergic rhinitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interferon lambda-2 |
|---|---|
| UniProt accession | Q8IZJ0 |
| Gene | IFNL2 |
| Organism | Homo sapiens |
| Length | 200 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (125)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.10
- neoplasm · score 0.08
- allergic rhinitis · score 0.08
- COVID-19 · score 0.06
- infection · score 0.05
- infect · score 0.05
- immunodeficiency 35 · score 0.05
- urinary bladder carcinoma · score 0.05
- immune deficiency, familial variable · score 0.05
- immunodeficiency 31B · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZJ0-F1 | alphafold | PREDICTED | 83.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZJ0.
Amino-acid sequence (200 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFNL2?
The strongest Open Targets associations for IFNL2 are ulcerative colitis, neoplasm, allergic rhinitis, COVID-19 and infection.
How long is the IFNL2 protein?
The Homo sapiens IFNL2 protein (UniProt Q8IZJ0) is 200 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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