Netrin receptor UNC5B (UNC5B)
Homo sapiens — UniProt Q8IZJ1
Data last refreshed: (UniProt release unknown)
Key facts
Netrin receptor UNC5B (UNC5B) is a protein from Homo sapiens identified by UniProt accession Q8IZJ1, 945 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.
- UniProt accession: Q8IZJ1; gene symbol UNC5B.
- Organism: Homo sapiens.
- Length: 945 amino acids.
- Top disease associations (Open Targets): chronotype measurement, vital capacity and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Netrin receptor UNC5B |
|---|---|
| UniProt accession | Q8IZJ1 |
| Gene | UNC5B |
| Organism | Homo sapiens |
| Length | 945 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (124)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.34
- vital capacity · score 0.27
- attention deficit hyperactivity disorder · score 0.26
- antisocial behaviour measurement · score 0.26
- substance abuse · score 0.26
- Varicose veins · score 0.26
- breast adenocarcinoma · score 0.24
- ovarian cancer · score 0.23
- pancreatic adenocarcinoma · score 0.21
- metabolite measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZJ1-F1 | alphafold | PREDICTED | 76.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZJ1.
Amino-acid sequence (945 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNC5B?
The strongest Open Targets associations for UNC5B are chronotype measurement, vital capacity, attention deficit hyperactivity disorder, antisocial behaviour measurement and substance abuse.
How long is the UNC5B protein?
The Homo sapiens UNC5B protein (UniProt Q8IZJ1) is 945 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZJ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZJ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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