Ral-GDS-related protein (RGL4)

About Ral-GDS-related protein

Ral-GDS-related protein (RGL4) is a protein from Homo sapiens identified by UniProt accession Q8IZJ4, 473 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Ral-GDS-related protein
UniProt accession	Q8IZJ4
Gene	RGL4
Organism	Homo sapiens
Length	473 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

adolescent idiopathic scoliosis · score 0.20
sex hormone-binding globulin measurement · score 0.04
Sepsis · score 0.03
IGF-1 measurement · score 0.03
osteosarcoma · score 0.02
septic shock · score 0.02
lung adenocarcinoma · score 0.02
cutaneous lupus erythematosus · score 0.01
neoplasm · score 0.01
cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IZJ4-F1	alphafold	PREDICTED	61.85	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZJ4.

Amino-acid sequence (473 residues)

MRKLLTNLPA AAVLSAQVYS AVLQGLWEEN VCGTPGRTRV CTALLYGQVC PFQDSTDGLR TITSILFNWP PENTSVYYQP PQRSSFRIKL AFRNLSWPGL GLEDHQEIVL GQLVLPEPNE AKPDDPAPRP GQHALTMPAL EPAPPLLADL GPALEPESPA ALGPPGYLHS APGPAPAPGE GPPPGTVLEP QSAPESSCPC RGSVKNQPSE ELPDMTTFPP RLLAEQLTLM DAELFKKVVL HECLGCIWGQ GHLKGNEHMA PTVRATIAHF NRLTNCITTS CLGDHSMRAR DRARVVEHWI KVARECLSLN NFSSVHVIVS ALCSNPIGQL HKTWAGVSSK SMKELKELCK KDTAVKRDLL IKAGSFKVAT QERNPQRVQM RLRRQKKGVV PFLGDFLTEL QRLDSAIPDD LDGNTNKRSK EVRVLQEMQL LQVAAMNYRL RPLEKFVTYF TRMEQLSDKE SYKLSCQLEP ENP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards