Mucolipin-2 (MCOLN2)
Homo sapiens — UniProt Q8IZK6
Data last refreshed: (UniProt release unknown)
Key facts
Mucolipin-2 (MCOLN2) is a protein from Homo sapiens identified by UniProt accession Q8IZK6, 566 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.
- UniProt accession: Q8IZK6; gene symbol MCOLN2.
- Organism: Homo sapiens.
- Length: 566 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, PHF-tau measurement and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mucolipin-2 |
|---|---|
| UniProt accession | Q8IZK6 |
| Gene | MCOLN2 |
| Organism | Homo sapiens |
| Length | 566 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- PHF-tau measurement · score 0.29
- glioblastoma multiforme · score 0.20
- breast adenocarcinoma · score 0.16
- hair color · score 0.13
- lung adenocarcinoma · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- hair colour measurement · score 0.11
- viral disease · score 0.06
- neutrophil immunodeficiency syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZK6-F1 | alphafold | PREDICTED | 81.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZK6.
Amino-acid sequence (566 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MCOLN2?
The strongest Open Targets associations for MCOLN2 are neurodegenerative disease, PHF-tau measurement, glioblastoma multiforme, breast adenocarcinoma and hair color.
How long is the MCOLN2 protein?
The Homo sapiens MCOLN2 protein (UniProt Q8IZK6) is 566 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZK6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZK6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.