Proline-, glutamic acid- and leucine-rich protein 1 (PELP1)
Homo sapiens — UniProt Q8IZL8
Data last refreshed: (UniProt release unknown)
Key facts
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) is a protein from Homo sapiens identified by UniProt accession Q8IZL8, 1130 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q8IZL8; gene symbol PELP1.
- Organism: Homo sapiens.
- Length: 1130 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, eosinophil count and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proline-, glutamic acid- and leucine-rich protein 1 |
|---|---|
| UniProt accession | Q8IZL8 |
| Gene | PELP1 |
| Organism | Homo sapiens |
| Length | 1130 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.20
- eosinophil count · score 0.20
- lymphocyte count · score 0.19
- endometrial cancer · score 0.18
- eosinophil percentage of leukocytes · score 0.18
- leukocyte count · score 0.17
- breast adenocarcinoma · score 0.15
- gastric adenocarcinoma · score 0.12
- Global developmental delay · score 0.11
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZL8-F1 | alphafold | PREDICTED | 63.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZL8.
Amino-acid sequence (1130 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PELP1?
The strongest Open Targets associations for PELP1 are lung adenocarcinoma, eosinophil count, lymphocyte count, endometrial cancer and eosinophil percentage of leukocytes.
How long is the PELP1 protein?
The Homo sapiens PELP1 protein (UniProt Q8IZL8) is 1130 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZL8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZL8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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