Dynein light chain Tctex-type protein 2 (DYNLT2)
Homo sapiens — UniProt Q8IZS6
Data last refreshed: (UniProt release unknown)
Key facts
Dynein light chain Tctex-type protein 2 (DYNLT2) is a protein from Homo sapiens identified by UniProt accession Q8IZS6, 198 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q8IZS6; gene symbol DYNLT2.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): vital capacity, smoking status measurement and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein light chain Tctex-type protein 2 |
|---|---|
| UniProt accession | Q8IZS6 |
| Gene | DYNLT2 |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.21
- smoking status measurement · score 0.10
- azoospermia · score 0.10
- self reported educational attainment · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- attention deficit hyperactivity disorder · score 0.07
- antisocial behaviour measurement · score 0.07
- substance abuse · score 0.07
- spermatogenic failure 65 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZS6-F1 | alphafold | PREDICTED | 76.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZS6.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DYNLT2?
The strongest Open Targets associations for DYNLT2 are vital capacity, smoking status measurement, azoospermia, self reported educational attainment and male infertility with teratozoospermia due to single gene mutation.
How long is the DYNLT2 protein?
The Homo sapiens DYNLT2 protein (UniProt Q8IZS6) is 198 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZS6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZS6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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