Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3)
Homo sapiens — UniProt Q8IZS8
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) is a protein from Homo sapiens identified by UniProt accession Q8IZS8, 1091 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.
- UniProt accession: Q8IZS8; gene symbol CACNA2D3.
- Organism: Homo sapiens.
- Length: 1091 amino acids.
- Top disease associations (Open Targets): cardiovascular disease, mathematical ability and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-dependent calcium channel subunit alpha-2/delta-3 |
|---|---|
| UniProt accession | Q8IZS8 |
| Gene | CACNA2D3 |
| Organism | Homo sapiens |
| Length | 1091 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (124)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.46
- mathematical ability · score 0.42
- blood protein measurement · score 0.39
- generalized anxiety disorder · score 0.39
- Polyuria · score 0.37
- gastrointestinal disease · score 0.37
- Urinary incontinence · score 0.37
- age at first sexual intercourse measurement · score 0.32
- attention deficit hyperactivity disorder · score 0.32
- lifestyle measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZS8-F1 | alphafold | PREDICTED | 82.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZS8.
Amino-acid sequence (1091 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CACNA2D3?
The strongest Open Targets associations for CACNA2D3 are cardiovascular disease, mathematical ability, blood protein measurement, generalized anxiety disorder and Polyuria.
How long is the CACNA2D3 protein?
The Homo sapiens CACNA2D3 protein (UniProt Q8IZS8) is 1091 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZS8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZS8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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