Heparan sulfate glucosamine 3-O-sulfotransferase 5 (HS3ST5)
Homo sapiens — UniProt Q8IZT8
Data last refreshed: (UniProt release unknown)
Key facts
Heparan sulfate glucosamine 3-O-sulfotransferase 5 (HS3ST5) is a protein from Homo sapiens identified by UniProt accession Q8IZT8, 346 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q8IZT8; gene symbol HS3ST5.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): smoking status measurement, iritis and daytime rest measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Heparan sulfate glucosamine 3-O-sulfotransferase 5 |
|---|---|
| UniProt accession | Q8IZT8 |
| Gene | HS3ST5 |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.33
- iritis · score 0.32
- daytime rest measurement · score 0.32
- mathematical ability · score 0.31
- self reported educational attainment · score 0.22
- cognitive decline measurement · score 0.18
- brain measurement · score 0.15
- neurodegenerative disease · score 0.13
- attention deficit hyperactivity disorder · score 0.04
- bone density · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZT8-F1 | alphafold | PREDICTED | 85.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZT8.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HS3ST5?
The strongest Open Targets associations for HS3ST5 are smoking status measurement, iritis, daytime rest measurement, mathematical ability and self reported educational attainment.
How long is the HS3ST5 protein?
The Homo sapiens HS3ST5 protein (UniProt Q8IZT8) is 346 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZT8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZT8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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