Synaptonemal complex protein 3 (SYCP3)
Homo sapiens — UniProt Q8IZU3
Data last refreshed: (UniProt release unknown)
Key facts
Synaptonemal complex protein 3 (SYCP3) is a protein from Homo sapiens identified by UniProt accession Q8IZU3, 236 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.
- UniProt accession: Q8IZU3; gene symbol SYCP3.
- Organism: Homo sapiens.
- Length: 236 amino acids.
- Top disease associations (Open Targets): habitual abortion, head and neck squamous cell carcinoma and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptonemal complex protein 3 |
|---|---|
| UniProt accession | Q8IZU3 |
| Gene | SYCP3 |
| Organism | Homo sapiens |
| Length | 236 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (203)
Diseases linked to this target (Open Targets).
- habitual abortion · score 0.60
- head and neck squamous cell carcinoma · score 0.23
- blood protein measurement · score 0.22
- osteoarthritis, knee · score 0.13
- male infertility · score 0.11
- azoospermia · score 0.10
- gastric adenocarcinoma · score 0.09
- familial atrial fibrillation · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZU3-F1 | alphafold | PREDICTED | 80.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZU3.
Amino-acid sequence (236 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SYCP3?
The strongest Open Targets associations for SYCP3 are habitual abortion, head and neck squamous cell carcinoma, blood protein measurement, osteoarthritis, knee and male infertility.
How long is the SYCP3 protein?
The Homo sapiens SYCP3 protein (UniProt Q8IZU3) is 236 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZU3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZU3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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