Dermatan-sulfate epimerase-like protein (DSEL)
Homo sapiens — UniProt Q8IZU8
Data last refreshed: (UniProt release unknown)
Key facts
Dermatan-sulfate epimerase-like protein (DSEL) is a protein from Homo sapiens identified by UniProt accession Q8IZU8, 1212 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q8IZU8; gene symbol DSEL.
- Organism: Homo sapiens.
- Length: 1212 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, drug use measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dermatan-sulfate epimerase-like protein |
|---|---|
| UniProt accession | Q8IZU8 |
| Gene | DSEL |
| Organism | Homo sapiens |
| Length | 1212 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- drug use measurement · score 0.14
- type 2 diabetes mellitus · score 0.06
- diabetic nephropathy · score 0.05
- intraocular pressure measurement · score 0.05
- lung carcinoma · score 0.01
- astrocytoma · score 0.01
- neoplasm · score 0.01
- invasive breast ductal carcinoma · score 0.01
- large cell medulloblastoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZU8-F1 | alphafold | PREDICTED | 85.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZU8.
Amino-acid sequence (1212 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DSEL?
The strongest Open Targets associations for DSEL are neurodegenerative disease, drug use measurement, type 2 diabetes mellitus, diabetic nephropathy and intraocular pressure measurement.
How long is the DSEL protein?
The Homo sapiens DSEL protein (UniProt Q8IZU8) is 1212 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZU8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZU8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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