Kin of IRRE-like protein 3 (KIRREL3)
Homo sapiens — UniProt Q8IZU9
Data last refreshed: (UniProt release unknown)
Key facts
Kin of IRRE-like protein 3 (KIRREL3) is a protein from Homo sapiens identified by UniProt accession Q8IZU9, 778 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.
- UniProt accession: Q8IZU9; gene symbol KIRREL3.
- Organism: Homo sapiens.
- Length: 778 amino acids.
- Top disease associations (Open Targets): diet measurement, neuroticism measurement and wellbeing measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kin of IRRE-like protein 3 |
|---|---|
| UniProt accession | Q8IZU9 |
| Gene | KIRREL3 |
| Organism | Homo sapiens |
| Length | 778 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (89)
Diseases linked to this target (Open Targets).
- diet measurement · score 0.45
- neuroticism measurement · score 0.39
- wellbeing measurement · score 0.38
- intellectual disability, autosomal dominant 4 · score 0.38
- autosomal dominant non-syndromic intellectual disability · score 0.37
- autism spectrum disorder · score 0.36
- mean corpuscular hemoglobin · score 0.33
- gut microbiome measurement · score 0.32
- mathematical ability · score 0.30
- drug use measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZU9-F1 | alphafold | PREDICTED | 72.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZU9.
Amino-acid sequence (778 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KIRREL3?
The strongest Open Targets associations for KIRREL3 are diet measurement, neuroticism measurement, wellbeing measurement, intellectual disability, autosomal dominant 4 and autosomal dominant non-syndromic intellectual disability.
How long is the KIRREL3 protein?
The Homo sapiens KIRREL3 protein (UniProt Q8IZU9) is 778 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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