Tensin-4 (TNS4)
Homo sapiens — UniProt Q8IZW8
Data last refreshed: (UniProt release unknown)
Key facts
Tensin-4 (TNS4) is a protein from Homo sapiens identified by UniProt accession Q8IZW8, 715 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q8IZW8; gene symbol TNS4.
- Organism: Homo sapiens.
- Length: 715 amino acids.
- Top disease associations (Open Targets): protein measurement, gut microbiome measurement and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tensin-4 |
|---|---|
| UniProt accession | Q8IZW8 |
| Gene | TNS4 |
| Organism | Homo sapiens |
| Length | 715 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.31
- gut microbiome measurement · score 0.29
- lung adenocarcinoma · score 0.28
- head and neck squamous cell carcinoma · score 0.19
- glioblastoma multiforme · score 0.19
- pancreatic adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.13
- neoplasm · score 0.10
- gonorrhea · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZW8-F1 | alphafold | PREDICTED | 59.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZW8.
Amino-acid sequence (715 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNS4?
The strongest Open Targets associations for TNS4 are protein measurement, gut microbiome measurement, lung adenocarcinoma, head and neck squamous cell carcinoma and glioblastoma multiforme.
How long is the TNS4 protein?
The Homo sapiens TNS4 protein (UniProt Q8IZW8) is 715 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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