Transcription initiation factor TFIID subunit 1-like (TAF1L)
Homo sapiens — UniProt Q8IZX4
Data last refreshed: (UniProt release unknown)
Key facts
Transcription initiation factor TFIID subunit 1-like (TAF1L) is a protein from Homo sapiens identified by UniProt accession Q8IZX4, 1826 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8IZX4; gene symbol TAF1L.
- Organism: Homo sapiens.
- Length: 1826 amino acids.
- Top disease associations (Open Targets): HIV infection, protein measurement and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription initiation factor TFIID subunit 1-like |
|---|---|
| UniProt accession | Q8IZX4 |
| Gene | TAF1L |
| Organism | Homo sapiens |
| Length | 1826 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.58
- protein measurement · score 0.25
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.25
- pancreatic adenocarcinoma · score 0.24
- lung adenocarcinoma · score 0.19
- endometrial cancer · score 0.18
- thyroid gland adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- colorectal adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8IZX4-F1 | alphafold | PREDICTED | 62.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8IZX4.
Amino-acid sequence (1826 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TAF1L?
The strongest Open Targets associations for TAF1L are HIV infection, protein measurement, breast adenocarcinoma, glioblastoma multiforme and pancreatic adenocarcinoma.
How long is the TAF1L protein?
The Homo sapiens TAF1L protein (UniProt Q8IZX4) is 1826 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8IZX4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8IZX4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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