Centromere protein L (CENPL)
Homo sapiens — UniProt Q8N0S6
Data last refreshed: (UniProt release unknown)
Key facts
Centromere protein L (CENPL) is a protein from Homo sapiens identified by UniProt accession Q8N0S6, 344 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q8N0S6; gene symbol CENPL.
- Organism: Homo sapiens.
- Length: 344 amino acids.
- Top disease associations (Open Targets): leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome, Leukoencephalopathy with brain stem and spinal cord involvement - high lactate and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centromere protein L |
|---|---|
| UniProt accession | Q8N0S6 |
| Gene | CENPL |
| Organism | Homo sapiens |
| Length | 344 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome · score 0.17
- Leukoencephalopathy with brain stem and spinal cord involvement - high lactate · score 0.17
- hepatocellular carcinoma · score 0.10
- breast cancer · score 0.09
- cancer · score 0.08
- alcohol consumption measurement · score 0.07
- pancreatic adenocarcinoma · score 0.07
- hemoglobin measurement · score 0.07
- lung adenocarcinoma · score 0.07
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0S6-F1 | alphafold | PREDICTED | 83.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0S6.
Amino-acid sequence (344 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CENPL?
The strongest Open Targets associations for CENPL are leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome, Leukoencephalopathy with brain stem and spinal cord involvement - high lactate, hepatocellular carcinoma, breast cancer and cancer.
How long is the CENPL protein?
The Homo sapiens CENPL protein (UniProt Q8N0S6) is 344 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0S6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0S6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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