Transmembrane protein 61 (TMEM61)
Homo sapiens — UniProt Q8N0U2
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 61 (TMEM61) is a protein from Homo sapiens identified by UniProt accession Q8N0U2, 210 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q8N0U2; gene symbol TMEM61.
- Organism: Homo sapiens.
- Length: 210 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, intermediate density lipoprotein measurement and desmosterolosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 61 |
|---|---|
| UniProt accession | Q8N0U2 |
| Gene | TMEM61 |
| Organism | Homo sapiens |
| Length | 210 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- intermediate density lipoprotein measurement · score 0.22
- desmosterolosis · score 0.17
- benign connective and soft tissue neoplasm · score 0.16
- total cholesterol measurement · score 0.06
- DNA methylation · score 0.04
- cardiovascular disease · score 0.03
- clear cell renal carcinoma · score 0.03
- wellbeing measurement · score 0.02
- alcohol consumption measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0U2-F1 | alphafold | PREDICTED | 59.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0U2.
Amino-acid sequence (210 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM61?
The strongest Open Targets associations for TMEM61 are neurodegenerative disease, intermediate density lipoprotein measurement, desmosterolosis, benign connective and soft tissue neoplasm and total cholesterol measurement.
How long is the TMEM61 protein?
The Homo sapiens TMEM61 protein (UniProt Q8N0U2) is 210 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0U2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0U2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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