Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1)
Homo sapiens — UniProt Q8N0U8
Data last refreshed: (UniProt release unknown)
Key facts
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) is a protein from Homo sapiens identified by UniProt accession Q8N0U8, 176 residues long. MolForge cross-references it against 1 known binders and 64 disease associations.
- UniProt accession: Q8N0U8; gene symbol VKORC1L1.
- Organism: Homo sapiens.
- Length: 176 amino acids.
- Top disease associations (Open Targets): monocyte count, central corneal thickness and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vitamin K epoxide reductase complex subunit 1-like protein 1 |
|---|---|
| UniProt accession | Q8N0U8 |
| Gene | VKORC1L1 |
| Organism | Homo sapiens |
| Length | 176 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.35
- central corneal thickness · score 0.34
- calcium measurement · score 0.31
- body height · score 0.27
- intraocular pressure measurement · score 0.26
- glomerular filtration rate · score 0.25
- hemoglobin A1 measurement · score 0.24
- blood phosphate measurement · score 0.20
- HbA1c measurement · score 0.19
- body weight · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0U8-F1 | alphafold | PREDICTED | 91.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0U8.
Amino-acid sequence (176 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VKORC1L1?
The strongest Open Targets associations for VKORC1L1 are monocyte count, central corneal thickness, calcium measurement, body height and intraocular pressure measurement.
How long is the VKORC1L1 protein?
The Homo sapiens VKORC1L1 protein (UniProt Q8N0U8) is 176 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0U8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0U8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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