Leucine-rich repeat LGI family member 2 (LGI2)
Homo sapiens — UniProt Q8N0V4
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat LGI family member 2 (LGI2) is a protein from Homo sapiens identified by UniProt accession Q8N0V4, 545 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q8N0V4; gene symbol LGI2.
- Organism: Homo sapiens.
- Length: 545 amino acids.
- Top disease associations (Open Targets): appendicitis, neurodegenerative disease and gut microbiome measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat LGI family member 2 |
|---|---|
| UniProt accession | Q8N0V4 |
| Gene | LGI2 |
| Organism | Homo sapiens |
| Length | 545 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- appendicitis · score 0.33
- neurodegenerative disease · score 0.33
- gut microbiome measurement · score 0.13
- BMI-adjusted waist circumference · score 0.07
- tonsillectomy risk measurement · score 0.03
- neutrophil count · score 0.02
- blood protein measurement · score 0.02
- Cough · score 0.02
- esophageal squamous cell carcinoma · score 0.01
- COVID-19 · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N0V4-F1 | alphafold | PREDICTED | 91.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N0V4.
Amino-acid sequence (545 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LGI2?
The strongest Open Targets associations for LGI2 are appendicitis, neurodegenerative disease, gut microbiome measurement, BMI-adjusted waist circumference and tonsillectomy risk measurement.
How long is the LGI2 protein?
The Homo sapiens LGI2 protein (UniProt Q8N0V4) is 545 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N0V4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N0V4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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